Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention

F1000Res. 2019 Apr 30:8:F1000 Faculty Rev-590. doi: 10.12688/f1000research.16160.1. eCollection 2019.

Abstract

Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras-mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.

Keywords: vascular tumors; vascular tumor management; genetics; hemangioma; Ras; MAPK; GNA14; GNA11; GNAQ; IDH.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Endothelial Cells / pathology
  • Humans
  • MAP Kinase Signaling System
  • Mutation
  • Vascular Neoplasms / genetics
  • Vascular Neoplasms / pathology*
  • ras Proteins / genetics

Substances

  • ras Proteins