Serious adverse events in patients with idiopathic pulmonary fibrosis in the placebo arms of 6 clinical trials

Respir Med. 2019 Apr:150:120-125. doi: 10.1016/j.rmed.2019.02.021. Epub 2019 Mar 13.

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by irreversible loss of lung function and an unpredictable course of disease progression.

Methods: The safety data for patients with IPF who received placebo in 6 clinical trials were pooled to examine the categories and frequencies of serious adverse events (SAEs) in this population.

Results: In 1082 patients with IPF who received placebo, 673 SAEs were reported. Of these, 93 SAEs resulted in death (8.6% of patients). Respiratory-related conditions were the most frequently reported SAE (225 events, 16.33 per 100 patient-exposure years [PEY]), followed by infections and infestations (136 events, 9.87 per 100 PEY) and cardiac disorders (79 events, 5.73 per 100 PEY); these categories also had the most fatal outcomes (60, 10, and 10 deaths, respectively). The most frequently reported fatal respiratory-related SAEs were IPF and respiratory failure (38 and 11 patients, respectively), and the most frequently reported fatal infections and infestations and cardiac disorders were pneumonia (5 patients) and myocardial infarction (3 patients), respectively.

Conclusions: This pooled analysis has value as a comparator for safety in future studies of IPF and provides insights in the natural evolution of both IPF and common comorbidities.

Keywords: Idiopathic pulmonary fibrosis; Interstitial lung disease; Safety.

Publication types

  • Clinical Trial, Phase II
  • Clinical Trial, Phase III
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Comorbidity
  • Disease Progression
  • Female
  • Heart Diseases / epidemiology
  • Humans
  • Idiopathic Pulmonary Fibrosis / drug therapy*
  • Idiopathic Pulmonary Fibrosis / epidemiology
  • Idiopathic Pulmonary Fibrosis / mortality*
  • Idiopathic Pulmonary Fibrosis / physiopathology
  • Infections / epidemiology
  • Lung Diseases, Interstitial / epidemiology
  • Lung Diseases, Interstitial / mortality
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Placebos / administration & dosage
  • Placebos / adverse effects*
  • Pneumonia / epidemiology
  • Respiratory Function Tests / methods
  • Respiratory Insufficiency / epidemiology
  • Safety / statistics & numerical data*

Substances

  • Placebos