Lysosomes Dare Cells to be Different(iated)

Agnes Roczniak-Ferguson; Shawn M Ferguson

doi:10.1016/j.stem.2019.01.007

Lysosomes Dare Cells to be Different(iated)

Cell Stem Cell. 2019 Feb 7;24(2):199-200. doi: 10.1016/j.stem.2019.01.007.

Authors

Agnes Roczniak-Ferguson¹, Shawn M Ferguson²

Affiliations

¹ Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA.
² Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: shawn.ferguson@yale.edu.

PMID: 30735644
DOI: 10.1016/j.stem.2019.01.007

Abstract

In this issue of Cell Stem Cell, Villegas et al. (2019) used a genome-wide CRISPR screen to identify ESC pluripotency regulators, which generated insights into how signaling from lysosome enables cells to transcriptionally regulate their metabolism. Further investigation of human genetics identified a human developmental disease arising from a defect in this process.

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MeSH terms

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Cell Differentiation
Embryonic Stem Cells*
Genome
Humans
Lysosomes
Pluripotent Stem Cells*

Substances

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
TFE3 protein, human