Abstract
In a recent study, Zhang et al. (Immunity 2019;50:121-136) report that adipocyte atrophy in aged skin increases susceptibility to bacterial infection. Enhanced TGF-β signaling in aged adipocyte progenitor cells induces a fibrotic cell fate that lacks antimicrobial peptides produced by mature adipocytes, highlighting the importance of stromal cells as innate immune effectors.
Keywords:
TGF-β; adipocyte; aging; bacterial infection; fibroblast.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adipocytes / metabolism*
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Adipocytes / pathology
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Adipogenesis
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Adipose Tissue, White / pathology*
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Aging / physiology*
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Animals
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Antimicrobial Cationic Peptides / metabolism
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Cathelicidins
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Disease Resistance
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Fibrosis
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Humans
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Immunity, Innate*
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Mice
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Skin Physiological Phenomena
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Staphylococcal Infections / immunology*
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Staphylococcus aureus / physiology*
Substances
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Antimicrobial Cationic Peptides
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Cathelicidins