Mycoplasma pneumoniae is an atypical bacterium that is frequently implicated in respiratory infections, but uncommonly identified as a cause of pericarditis. We report 2 cases of pericarditis attributed to M. pneumoniae that were characterized by prolonged respiratory prodromes, pericardial, and pleural effusions, elevated inflammatory markers, and relapsing clinical courses. In conclusion, our experience suggests that M. pneumoniae should be considered as a potential cause in cases of pericarditis associated with upper respiratory symptoms, pneumonia, pleural effusions, arthralgia, and/or a recurrent/refractory clinical course. The availability of effective antibiotic treatment makes this an important diagnosis to make.
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