To BBB or Not to BBB?

Dev Cell. 2018 Dec 17;47(6):689-691. doi: 10.1016/j.devcel.2018.11.039.

Abstract

In this issue of Developmental Cell, Anbalagan et al. demonstrate that pituicytes, a subtype of astroglia, drive endothelial cell permeability in the zebrafish embryo neurohypophysis. This occurs via secretion of Vegfa/Tgfβ3 permeability factors that promote formation of fenestrae and the repression of anti-inflammatory retinoic acid signaling that induces tight cell junctions.

Publication types

  • Comment

MeSH terms

  • Animals
  • Blood-Brain Barrier*
  • Cues
  • Permeability
  • Pituitary Gland, Posterior*
  • Tight Junctions