Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety

AIDS Behav. 2019 Aug;23(8):2048-2058. doi: 10.1007/s10461-018-2344-6.

Abstract

With adequate support, people with HIV (PWH) may achieve high levels of adherence to antiretroviral therapy (ART) during incarceration. We examined factors associated with ART utilization and adherence among incarcerated PWH (N = 150) in Indonesia. ART utilization was positively associated with HIV status disclosure (adjusted odds ratio [aOR] = 5.5, 95% CI 1.2-24.1, p = 0.023), drug dependency (aOR = 3.9, 95% CI 1.2-12.6, p = 0.022), health service satisfaction (aOR = 3.2, 95% CI 1.7-6.2, p < 0.001), and perceived need for medical treatment (aOR = 1.6, 95% CI 1.1-2.5, p = 0.011), and negatively associated with chance locus of control (aOR = 0.3, 95% CI 0.1-0.7, p = 0.013). Most participants utilizing ART (74.5%) reported less than "perfect" ART adherence. ART adherence was independently associated with perceived personal safety (β = 0.21, 95% CI 0.01-0.40, p = 0.032) and methadone utilization (β = 0.84, 95% CI 0.10-1.67, p = 0.047). PWH receiving methadone had a sixfold higher adjusted odds of being highly-adherent to ART (aOR = 6.3, 95% CI 1.1-35.7, p = 0.036). Interventions that increase methadone utilization and personal safety may improve ART adherence among incarcerated PWH.

Keywords: Adherence; Antiretroviral therapy; HIV; Methadone; Prisons; Substance use.

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active / methods*
  • Cross-Sectional Studies
  • HIV
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / psychology
  • Humans
  • Indonesia / epidemiology
  • Male
  • Medication Adherence / psychology*
  • Medication Adherence / statistics & numerical data
  • Methadone / therapeutic use
  • Odds Ratio
  • Opiate Substitution Treatment
  • Prisoners / psychology*
  • Substance-Related Disorders

Substances

  • Methadone