Rotten to the Core: Why Micronuclei Rupture

Dev Cell. 2018 Nov 5;47(3):265-266. doi: 10.1016/j.devcel.2018.10.023.

Abstract

A recent study in Nature from Liu et al. (2018) suggests that the rupture of micronuclei and resulting exposure of genomic DNA to the cytosol is driven by microtubule-induced defects in the biochemical composition of their bounding membranes.

Publication types

  • Comment

MeSH terms

  • Chromothripsis
  • DNA
  • DNA Damage
  • Humans
  • Micronuclei, Chromosome-Defective*
  • Nuclear Envelope*

Substances

  • DNA