T-cell lymphoblastic lymphoma involving the ocular adnexa: report of two cases and review of the current literature

Orbit. 2019 Oct;38(5):412-418. doi: 10.1080/01676830.2018.1540013. Epub 2018 Nov 6.

Abstract

The majority of ocular adnexal lymphomas are B-cell in origin. We report two cases of T-cell lymphoblastic lymphoma (T-LBL) involving the ocular adnexa. One patient presented with a painless pink conjunctival lesion and inferior orbital fullness. The second patient presented with a painless orbital mass. The diagnoses were confirmed by histopathology and immunohistochemistry. Both patients had extensive multifocal lesions during staging. Prompt intensified chemotherapy regimens were initiated. T-LBL is an aggressive disease with poor prognosis. This report emphasizes the importance of timely diagnosis by the ophthalmologist with co-management and treatment with an oncologist.

Keywords: T-cell; lymphoblastic lymphoma; ocular adnexa; orbit; precursor.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Biopsy
  • Conjunctival Neoplasms / diagnostic imaging
  • Conjunctival Neoplasms / metabolism
  • Conjunctival Neoplasms / pathology*
  • Conjunctival Neoplasms / surgery
  • Humans
  • Male
  • Neoplasm Proteins / metabolism
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / metabolism
  • Orbital Neoplasms / pathology*
  • Orbital Neoplasms / surgery
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / diagnostic imaging
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / surgery
  • Tomography, X-Ray Computed
  • Young Adult

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins