Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata

Arihiro Iwasaki; Takato Tadenuma; Shimpe Sumimoto; Ikuma Shiota; Teruhiko Matsubara; Yumiko Saito-Nakano; Tomoyoshi Nozaki; Toshinori Sato; Kiyotake Suenaga

doi:10.1021/acs.jnatprod.8b00643

Hoshinoamides A and B, Acyclic Lipopeptides from the Marine Cyanobacterium Caldora penicillata

J Nat Prod. 2018 Nov 26;81(11):2545-2552. doi: 10.1021/acs.jnatprod.8b00643. Epub 2018 Nov 2.

Authors

Arihiro Iwasaki¹, Takato Tadenuma¹, Shimpe Sumimoto¹, Ikuma Shiota¹, Teruhiko Matsubara², Yumiko Saito-Nakano³, Tomoyoshi Nozaki⁴, Toshinori Sato², Kiyotake Suenaga¹

Affiliations

¹ Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi, Kohoku-ku , Yokohama , Kanagawa 223-8522 , Japan.
² Department of Biosciences and Informatics, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi, Kohoku-ku , Yokohama , Kanagawa 223-8522 , Japan.
³ Department of Parasitology , National Institute of Infectious Diseases , 1-23-1 Toyama, Shinjuku-ku , Tokyo 162-8640 , Japan.
⁴ Department of Biomedical Chemistry, Graduate School of Medicine , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku , Tokyo 113-0033 , Japan.

PMID: 30387355
DOI: 10.1021/acs.jnatprod.8b00643

Abstract

Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC₅₀ = 0.52 and 1.0 μM, respectively).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyanobacteria / chemistry*
HeLa Cells
Humans
Lipopeptides / isolation & purification*
Lipopeptides / pharmacology*
Seawater / microbiology*
Water Microbiology

Substances

Lipopeptides