Frontiers in pigment cell and melanoma research

Fabian V Filipp; Stanca Birlea; Marcus W Bosenberg; Douglas Brash; Pamela B Cassidy; Suzie Chen; John A D'Orazio; Mayumi Fujita; Boon-Kee Goh; Meenhard Herlyn; Arup K Indra; Lionel Larue; Sancy A Leachman; Caroline Le Poole; Feng Liu-Smith; Prashiela Manga; Lluis Montoliu; David A Norris; Yiqun Shellman; Keiran S M Smalley; Richard A Spritz; Richard A Sturm; Susan M Swetter; Tamara Terzian; Kazumasa Wakamatsu; Jeffrey S Weber; Neil F Box

doi:10.1111/pcmr.12728

Frontiers in pigment cell and melanoma research

Pigment Cell Melanoma Res. 2018 Nov;31(6):728-735. doi: 10.1111/pcmr.12728. Epub 2018 Oct 3.

Authors

Fabian V Filipp¹, Stanca Birlea², Marcus W Bosenberg³, Douglas Brash⁴, Pamela B Cassidy⁵, Suzie Chen⁶, John A D'Orazio⁷, Mayumi Fujita², Boon-Kee Goh⁸, Meenhard Herlyn⁹, Arup K Indra^{5

10}, Lionel Larue¹¹, Sancy A Leachman⁵, Caroline Le Poole¹², Feng Liu-Smith¹³, Prashiela Manga¹⁴, Lluis Montoliu¹⁵, David A Norris², Yiqun Shellman², Keiran S M Smalley¹⁶, Richard A Spritz¹⁷, Richard A Sturm¹⁸, Susan M Swetter¹⁹, Tamara Terzian², Kazumasa Wakamatsu²⁰, Jeffrey S Weber²¹, Neil F Box²

Affiliations

¹ Systems Biology and Cancer Metabolism, Program for Quantitative Systems Biology, University of California Merced, Merced, California.
² Department of Dermatology, University of Colorado Denver, Aurora, Colorado.
³ Department of Dermatology and Dermatopathology, Yale School of Medicine, New Haven, Connecticut.
⁴ Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut.
⁵ Department of Dermatology, Oregon Health and Science University, Portland, Oregon.
⁶ Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey.
⁷ Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky.
⁸ Mount Elizabeth Medical Centre, Skin Physicians Private Limited, Singapore, Singapore.
⁹ Department of Molecular and Cellular Oncogenesis, Wistar Institute, Philadelphia, Pennsylvania.
¹⁰ Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon.
¹¹ Equipe Labellisée Ligue Contre le Cancer, Normal and Pathological Development of Melanocytes, UMR 3347, CNRS, Institut Curie, Orsay, France.
¹² Lurie Comprehensive Cancer Center, Northwestern University at Chicago, Chicago, Illinois.
¹³ Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, California.
¹⁴ Ronald O Perlman Department of Dermatology, New York University Langone Medical Center, New York, New York.
¹⁵ CNB-CSIC, CIBERER-ISCIII, Campus de Cantoblanco, Centro Nacional de Biotecnología, Madrid, Spain.
¹⁶ Department of Tumor Biology, Moffitt Cancer Center, Tampa, Florida.
¹⁷ Human Medical Genetics and Genomics Program, University of Colorado Denver, Aurora, Colorado.
¹⁸ Dermatology Research Centre, University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia.
¹⁹ Department of Dermatology, Stanford University, Palo Alto, California.
²⁰ Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan.
²¹ Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York.

Abstract

In this perspective, we identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology. Significantly, this document encapsulates important advances in melanocyte and melanoma research including emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, epidemiology, pigment biophysics and chemistry, and evolution.

Keywords: International Pigment Cell Conference; UV; albinism; cancer prevention; dermatology; immunotherapy; melanin; melanocyte; melanoma; melasma; pigmentation; skin; vitiligo.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Biomedical Research*
Disease Models, Animal
Drug Resistance, Neoplasm
Humans
Melanocytes / pathology*
Melanoma / epidemiology
Melanoma / pathology*
Melanoma / prevention & control
Melanoma / therapy
Pigmentation

Abstract

Publication types

MeSH terms

Grants and funding