Gut Microbiota: IgA Protects the Pioneers

Whitman B Schofield; Noah W Palm

doi:10.1016/j.cub.2018.08.019

Gut Microbiota: IgA Protects the Pioneers

Curr Biol. 2018 Sep 24;28(18):R1117-R1119. doi: 10.1016/j.cub.2018.08.019.

Authors

Whitman B Schofield¹, Noah W Palm²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: whitman.schofield@yale.edu.
² Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: noah.palm@yale.edu.

PMID: 30253156
DOI: 10.1016/j.cub.2018.08.019

Abstract

The secretory antibody immunoglobulin A counteracts pathogenic infections at mucosal surfaces. Recent work now reveals that IgA responses can also stabilize intestinal colonization by symbiotic microorganisms and confer resistance to future invasion by exogenous competitors.

Publication types

Comment

MeSH terms

Gastrointestinal Microbiome*
Immunoglobulin A
Immunoglobulin A, Secretory
Intestinal Mucosa
Intestines

Substances

Immunoglobulin A
Immunoglobulin A, Secretory