Antigen reactive memory T cells are defined by Ta1

J Immunol. 1986 Jul 15;137(2):414-8.

Abstract

Ta1 is a 105,000 dalton protein that is weakly expressed on a small fraction of resting human peripheral blood T cells but strongly expressed in vitro on T cell clones and a substantial proportion of activated T cells. Unlike receptors for growth factors such as IL 2, the Ta1 antigen is present on T cell lines and clones irrespective of cell cycle. The function of Ta1 was investigated after separation of T lymphocytes into Ta1-enriched and Ta1-depleted subpopulations that were obtained from normal human subjects. Although Ta1-enriched T cells constitute only 10 to 15% of the E rosette-positive lymphocyte population, most, if not all, of the anamnestic response to the recall antigens tetanus toxoid and mumps reside in the Ta1+ population. Both Ta1-enriched and -depleted cells responded equally well to the mitogen PHA. The autologous mixed lymphocyte response was also greater in the Ta1-enriched subpopulation but not to the degree seen with soluble antigen. Increased proliferation was not due simple to increased inducer cell function within the Ta1+ subpopulations because both Ta1- and Ta1+ cells induced similar amounts of Ig synthesis in the presence of PWM. Additionally, increasing numbers of Ta1- cells did not suppress the enhanced proliferative responses of Ta1+ cells, and thus Ta1- cells do not appear to be functioning as suppressor cells. The Ta1 antigen appears to be a marker for previously activated T cells in peripheral blood, and this subpopulation appears to include T memory cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Surface / immunology*
  • Cell Separation
  • Humans
  • Immunoglobulins / biosynthesis
  • Immunologic Memory*
  • Kinetics
  • Lymphocyte Activation*
  • Lymphocyte Culture Test, Mixed
  • Mumps virus / immunology
  • Pokeweed Mitogens / pharmacology
  • T-Lymphocytes / classification
  • T-Lymphocytes / immunology*
  • Tetanus Toxoid / immunology
  • Tumor Necrosis Factor Receptor Superfamily, Member 7

Substances

  • Antigens, Surface
  • Immunoglobulins
  • Pokeweed Mitogens
  • Tetanus Toxoid
  • Tumor Necrosis Factor Receptor Superfamily, Member 7