Abstract
Two new jahanyne analogues, jahanene and jahanane, highly N-methylated lipopeptides, were isolated from a marine cyanobacterium Okeania sp., and their structures were determined by NMR and MS. In addition, we achieved total syntheses of the jahanyne family and assessed their activities. The resulting growth-inhibitory activity of jahanyne was nearly one-tenth of the previously reported activity. Furthermore, we found that the degree of unsaturation at the terminus of the fatty acid moiety affected the growth-inhibitory activity against human cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cell Proliferation / drug effects
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Chemistry Techniques, Synthetic
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Cyanobacteria / chemistry
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Fatty Acids / chemistry
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HeLa Cells
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Humans
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Lipopeptides / chemical synthesis*
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Lipopeptides / chemistry
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Lipopeptides / isolation & purification*
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Lipopeptides / pharmacology
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Fatty Acids
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Lipopeptides
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jahanyne