Resident Endothelial Progenitors Make Themselves at Home

Karen K Hirschi; Elisabetta Dejana

doi:10.1016/j.stem.2018.07.014

Resident Endothelial Progenitors Make Themselves at Home

Cell Stem Cell. 2018 Aug 2;23(2):153-155. doi: 10.1016/j.stem.2018.07.014.

Authors

Karen K Hirschi¹, Elisabetta Dejana²

Affiliations

¹ Departments of Medicine, Genetics, and Biomedical Engineering, Yale Cardiovascular Research Center and Yale Stem Cell Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: karen.hirschi@yale.edu.
² FIRC Institute of Molecular Oncology, Milan, Italy; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden. Electronic address: elisabetta.dejana@ifom.eu.

PMID: 30075124
DOI: 10.1016/j.stem.2018.07.014

Abstract

Vascular endothelial cells adapt to their microenvironment and physiological demands to perform many essential functions. Recent studies (McDonald et al., 2018; Wakabayashi et al., 2018) suggest that quiescent endothelial stem/progenitor cells reside within blood vessels and are activated in response to injury, suggesting they can be harnessed for therapeutic applications.

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MeSH terms

Regeneration*
Stem Cells*