Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis

Mark C Horowitz; Steven M Tommasini

doi:10.1016/j.stem.2018.07.010

Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis

Cell Stem Cell. 2018 Aug 2;23(2):151-153. doi: 10.1016/j.stem.2018.07.010.

Authors

Mark C Horowitz¹, Steven M Tommasini²

Affiliations

¹ Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: mark.horowitz@yale.edu.
² Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT 06510, USA.

PMID: 30075123
DOI: 10.1016/j.stem.2018.07.010

Abstract

PGC-1α is a transcriptional co-activator associated with PPARγ that regulates thermogenic gene expression in brown fat. In this issue, Yu et al. (2018) show that PGC-1α regulates marrow mesenchymal stromal cell lineage allocation in vivo, inhibiting marrow adipogenesis and associated bone loss in the aging skeleton and following ovariectomy-induced osteoporosis.

Publication types

Comment

MeSH terms

Adipogenesis
Adipose Tissue, Brown
Cell Differentiation
Female
Humans
Mesenchymal Stem Cells*
Osteoporosis*
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Substances

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Grants and funding

R24 DK092759/DK/NIDDK NIH HHS/United States