Successful treatment of primary donor-derived human herpesvirus-8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient

Whitney Fu; Jonathan Merola; Maricar Malinis; Jill Lacy; Andrea Barbieri; Annmarie H Liapakis; David C Mulligan; Peter S Yoo

doi:10.1111/tid.12966

Successful treatment of primary donor-derived human herpesvirus-8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient

Transpl Infect Dis. 2018 Oct;20(5):e12966. doi: 10.1111/tid.12966. Epub 2018 Aug 23.

Authors

Whitney Fu¹, Jonathan Merola¹, Maricar Malinis², Jill Lacy², Andrea Barbieri³, Annmarie H Liapakis², David C Mulligan¹, Peter S Yoo¹

Affiliations

¹ Departments of Surgery, Yale School of Medicine, New Haven, Connecticut.
² Departments of Medicine, Yale School of Medicine, New Haven, Connecticut.
³ Departments of Pathology, Yale School of Medicine, New Haven, Connecticut.

PMID: 30014622
DOI: 10.1111/tid.12966

Abstract

Kaposi sarcoma (KS) may rarely occur in transplant recipients through primary human herpesvirus-8 (HHV-8) infection from a seropositive donor. This report describes a patient who developed hepatic KS after receiving a split liver transplant from an HHV-8-positive donor. The recipient was treated with liposomal doxorubicin after reduction in immunosuppression led to acute cellular rejection. This treatment achieved regression of KS while preserving allograft function, demonstrating a successful therapeutic strategy for this malignancy.

Keywords: human herpesvirus-8; liver transplant; post-transplant Kaposi Sarcoma.

Publication types

Case Reports

MeSH terms

Allografts / diagnostic imaging
Allografts / pathology
Allografts / virology
Doxorubicin / analogs & derivatives*
Doxorubicin / therapeutic use
Female
Herpesviridae Infections / diagnosis
Herpesviridae Infections / pathology
Herpesviridae Infections / transmission*
Herpesviridae Infections / virology
Herpesvirus 8, Human / isolation & purification
Humans
Liver / diagnostic imaging
Liver / pathology
Liver / virology
Liver Neoplasms / diagnosis
Liver Neoplasms / drug therapy*
Liver Neoplasms / pathology
Liver Neoplasms / virology
Liver Transplantation / adverse effects*
Magnetic Resonance Imaging
Male
Middle Aged
Polyethylene Glycols / therapeutic use
Sarcoma, Kaposi / diagnosis
Sarcoma, Kaposi / drug therapy*
Sarcoma, Kaposi / pathology
Sarcoma, Kaposi / virology
Tissue Donors
Transplantation, Homologous / adverse effects
Treatment Outcome
Young Adult

Substances

liposomal doxorubicin
Polyethylene Glycols
Doxorubicin