Viral Vectors for Studying Brain Mechanisms that Control Energy Homeostasis

Giacomo Mancini; Tamas L Horvath

doi:10.1016/j.cmet.2018.05.015

Viral Vectors for Studying Brain Mechanisms that Control Energy Homeostasis

Cell Metab. 2018 Jun 5;27(6):1168-1175. doi: 10.1016/j.cmet.2018.05.015.

Authors

Giacomo Mancini¹, Tamas L Horvath²

Affiliations

¹ Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: giacomo.mancini@yale.edu.
² Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary. Electronic address: tamas.horvath@yale.edu.

PMID: 29874565
DOI: 10.1016/j.cmet.2018.05.015

Abstract

Viral vectors have been shown to be potent and versatile tools for genome editing. In the present Minireview, we focus on lentiviruses and adeno-associated viruses as vectors and their use in the study of the hypothalamic circuits involved in the regulation of energy homeostasis.

Publication types

Review

MeSH terms

Animals
Dependovirus*
Energy Metabolism*
Genetic Therapy
Genetic Vectors*
Homeostasis*
Humans
Hypothalamus / physiology*
Lentivirus*
Mice