Peptide-Mediated Neurotransmission Takes Center Stage

Aneysis D Gonzalez-Suarez; Michael N Nitabach

doi:10.1016/j.tins.2018.03.013

Peptide-Mediated Neurotransmission Takes Center Stage

Trends Neurosci. 2018 Jun;41(6):325-327. doi: 10.1016/j.tins.2018.03.013.

Authors

Aneysis D Gonzalez-Suarez¹, Michael N Nitabach²

Affiliations

¹ Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA.
² Department of Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA; Department of Genetics, Yale University, New Haven, CT 06520, USA; Kavli Institute for Neuroscience, Yale University, New Haven, CT 06520, USA. Electronic address: michael.nitabach@yale.edu.

Abstract

Today, we understand peptide transmitters to be signaling molecules that modulate neural activity. However, in 1982 little was known about neuropeptides and their role in neural communication. The influential 1982 paper by Jan and Jan reported definitive evidence that a presynaptically released neuropeptide evokes postsynaptic responses in an identified cholinergic synapse, thereby fueling a new era in neuroscience.

Keywords: LHRH; neuropeptides; neurotransmission; peptide transmitters; signaling molecules.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Neuropeptides / metabolism
Neuropeptides / pharmacology*
Presynaptic Terminals / drug effects*
Presynaptic Terminals / metabolism*
Synaptic Transmission / drug effects*
Synaptic Transmission / physiology

Substances

Neuropeptides

Abstract

Publication types

MeSH terms

Substances

Grants and funding