Crown ether microfunctionalized carbon nanotubes for dispersive micro-solid-phase extraction of sudan dyes and their metabolites

Food Chem. 2018 Oct 1:262:118-128. doi: 10.1016/j.foodchem.2018.04.072. Epub 2018 Apr 22.

Abstract

In this study, dispersive micro solid phase extraction (DMSPE) combined with ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry method was established to extract and determine sudan dyes and their metabolites in real samples. The crown ether microfunctionalized multi-walled carbon nanotubes (MWCNTs) was applied as the sorbent in DMSPE procedure. Several experimental parameters that can effect the extraction performance of the DMSPE method were investigated separately by a univariate method. The validation data showed that the limits of detection were in the range of 0.084-13.13 μg/kg, the mean recoveries were ranged from 80.15 to 103.58% for six samples. Compared with other published methods, the proposed method was more effective, more time-saving and more eco-friendly. Finally, the developed method was successfully applied to enrich and detect sudan dyes and their metabolites in real samples.

Keywords: Crown ether; Dispersive micro solid phase extraction; Food analysis; Microfunctionalized carbon nanotubes; Sudan dyes and their metabolites; Ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

MeSH terms

  • Azo Compounds / analysis
  • Azo Compounds / isolation & purification*
  • Chromatography, High Pressure Liquid / methods*
  • Coloring Agents / analysis
  • Coloring Agents / isolation & purification*
  • Crown Ethers / chemistry
  • Food Analysis / methods*
  • Limit of Detection
  • Nanotubes, Carbon / chemistry
  • Solid Phase Microextraction / methods*
  • Tandem Mass Spectrometry / methods*

Substances

  • Azo Compounds
  • Coloring Agents
  • Crown Ethers
  • Nanotubes, Carbon