Classification of the insulin-like growth factor binding proteins into three distinct categories according to their binding specificities

Biochem Biophys Res Commun. 1988 Nov 30;157(1):196-202. doi: 10.1016/s0006-291x(88)80032-9.

Abstract

Competitive binding experiments with insulin-like growth factor (IGF)-1, IGF-2 and des-(1-3)-IGF-1 have confirmed the interpretation based on limited amino-terminal sequence analysis that at least three types of IGF binding protein occur. In addition to the acid stable subunit of the large serum binding protein which exhibits des-(1-3)-IGF-1 binding only slightly less than IGF-1, the small IGF binding proteins can be separated into two classes based on differences in des-(1-3)-IGF-1 and IGF-2 binding potencies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive
  • Cattle
  • Cell Line
  • Humans
  • Kidney / metabolism
  • Peptide Fragments / metabolism
  • Receptor, Insulin / classification*
  • Receptor, Insulin / metabolism
  • Receptors, Somatomedin
  • Recombinant Proteins / metabolism
  • Somatomedins / metabolism*
  • Structure-Activity Relationship

Substances

  • Peptide Fragments
  • Receptors, Somatomedin
  • Recombinant Proteins
  • Somatomedins
  • Receptor, Insulin