Anti-thrombogenicity and permeability of polyethersulfone hollow fiber membrane with sulfonated alginate toward blood purification

Int J Biol Macromol. 2018 Sep:116:364-377. doi: 10.1016/j.ijbiomac.2018.04.137. Epub 2018 Apr 30.

Abstract

The main aim of this study was to evaluate the suitability of sulfonated alginate as a modifying agent to enhance the hemocompatibility of self-fabricated polyethersulfone (PES) hollow fiber membrane for blood detoxification. Sodium alginate was sulfonated with a degree of 0.6 and immobilized on the membrane via surface amination and using glutaraldehyde as cross-linking agent. Coating layer not only improved the membrane surface hydrophilicity, but also induced -39.2 mV negative charges on the surface. Water permeability of the modified membrane was enhanced from 67 to 95 L/m2·h·bar and flux recovery ratio increased more than 2-fold. Furthermore, the modified membrane presented higher platelet adhesion resistance (reduced by more than 90%) and prolonged coagulation time (35 s for APTT and 14 s for PT) in comparison with the pristine PES hollow fiber membrane, which verified the improved anti-thrombogenicity of the modified membrane. On the other hand, obtained membrane after 3 h coating could remove up-to 60% of the uremic toxins. According to the obtained data, sulfonated alginate can be a promising modifying agent for the future blood-contacting membrane and specially blood purification issues.

Keywords: Blood compatible; Heparin-like; Hollow fiber membrane; Polyethersulfone.

MeSH terms

  • Adult
  • Alginates / pharmacology*
  • Biocompatible Materials / pharmacology
  • Blood / drug effects*
  • Blood Coagulation / drug effects
  • Cross-Linking Reagents / pharmacology
  • Fibrinolytic Agents / pharmacology*
  • Glucuronic Acid / pharmacology
  • Hexuronic Acids / pharmacology
  • Humans
  • Hydrophobic and Hydrophilic Interactions / drug effects
  • Male
  • Membranes, Artificial
  • Permeability / drug effects*
  • Platelet Adhesiveness / drug effects
  • Polymers / pharmacology*
  • Sulfones / pharmacology*

Substances

  • Alginates
  • Biocompatible Materials
  • Cross-Linking Reagents
  • Fibrinolytic Agents
  • Hexuronic Acids
  • Membranes, Artificial
  • Polymers
  • Sulfones
  • polyether sulfone
  • Glucuronic Acid