DUSPs, twists and turns in the Journey to Vascular Inflammation

FEBS J. 2018 May;285(9):1589-1592. doi: 10.1111/febs.14461. Epub 2018 Apr 22.

Abstract

The MAPK phosphatase DUSP6/MKP-3 dephosphorylates ERK1 and 2 and negatively regulates ERK-dependent signaling. Hsu et al. now show that DUSP6/MKP-3 is required for the TNF-α-induced upregulation of the endothelial cell adhesion molecule-1 (ICAM-1) and neutrophil infiltration in endothelial cells, and interestingly, this positive role of DUSP6 on the inflammatory process is independent of ERK signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Dual Specificity Phosphatase 6
  • Dual-Specificity Phosphatases*
  • Endothelial Cells
  • Humans
  • Inflammation
  • Intercellular Adhesion Molecule-1*
  • Mitogen-Activated Protein Kinase 3

Substances

  • Intercellular Adhesion Molecule-1
  • Mitogen-Activated Protein Kinase 3
  • DUSP6 protein, human
  • Dual Specificity Phosphatase 6
  • Dual-Specificity Phosphatases