Ypaoamides B and C, Linear Lipopeptides from an Okeania sp. Marine Cyanobacterium

J Nat Prod. 2018 Apr 27;81(4):1103-1107. doi: 10.1021/acs.jnatprod.8b00088. Epub 2018 Apr 18.

Abstract

Two new pyrrolinone-containing lipopeptides, ypaoamides B (1) and C (2), were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. Their structures were determined by spectroscopic analysis and Marfey's analysis of acid hydrolysates. Ypaoamides B (1) and C (2) stimulated glucose uptake in cultured rat L6 myotubes. In particular, ypaoamide B (1) showed potent activity and activated AMP-activated protein kinase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aquatic Organisms / chemistry*
  • Cell Line
  • Cyanobacteria / chemistry*
  • Drug Screening Assays, Antitumor / methods
  • Lipopeptides / chemistry*
  • Pyrrolidines / chemistry*
  • Rats
  • Structure-Activity Relationship

Substances

  • Lipopeptides
  • Pyrrolidines
  • ypaoamide