12/15 lipoxygenase: A crucial enzyme in diverse types of cell death

Neurochem Int. 2018 Sep:118:34-41. doi: 10.1016/j.neuint.2018.04.002. Epub 2018 Apr 5.

Abstract

The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty acids producing active lipid metabolites that are involved in plethora of human diseases including neurological disorders. A great many of elegant studies over the last decades have contributed to unraveling the mechanism how 12/15-lipoxygenase play a role in these diseases. And the way it works is mainly through apoptosis. However, recent years have found that the way 12/15-lipoxygenase works is also related to autophagy and ferroptosis, a newly defined type of cell death by Stockwell's lab in 2012. Figuring out how 12/15-lipoxygenase participate in these modes of cell death is of vital importance to understand its role in disease. The review aims to give a sight on our current knowledge on the role of this enzyme in apoptosis, autophagy and ferroptosis. And the relevant diseases that 12/15-lipoxygenase may be involved.

Keywords: 12/15-LOX; Apoptosis; Autophagy; Diseases; Ferroptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Arachidonate 12-Lipoxygenase / metabolism*
  • Arachidonate 15-Lipoxygenase / metabolism*
  • Autophagy / physiology*
  • Cell Death / physiology
  • Humans
  • Nervous System Diseases / enzymology
  • Nervous System Diseases / pathology

Substances

  • 12-15-lipoxygenase
  • Arachidonate 12-Lipoxygenase
  • Arachidonate 15-Lipoxygenase