The ABCs of PTMs

Nat Chem Biol. 2018 Feb 14;14(3):188-192. doi: 10.1038/nchembio.2572.

Abstract

Post-translational modifications (PTMs) are ubiquitous in all forms of life and often modulate critical protein functions. Recent chemical and biological advances have finally enabled scientists to precisely modify proteins at physiologically-relevant positions ushering in a new era of protein studies.

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Escherichia coli / metabolism
  • Genome
  • Glycosylation
  • Humans
  • Peptides / chemistry
  • Phosphorylation
  • Protein Engineering
  • Protein Processing, Post-Translational*
  • Proteome
  • Recombinant Proteins / chemistry*
  • Ribosomes / chemistry*
  • Substrate Specificity
  • Synthetic Biology / methods*
  • Ubiquitin / chemistry

Substances

  • Peptides
  • Proteome
  • Recombinant Proteins
  • Ubiquitin