On the Path from Proteomics to Function: GABAAR Trafficking Takes a Turn

Yoav Noam; Susumu Tomita

doi:10.1016/j.neuron.2018.01.038

On the Path from Proteomics to Function: GABA_AR Trafficking Takes a Turn

Neuron. 2018 Feb 7;97(3):479-481. doi: 10.1016/j.neuron.2018.01.038.

Authors

Yoav Noam¹, Susumu Tomita²

Affiliations

¹ Department of Cellular and Molecular Physiology, Department of Neuroscience, CNNR program, Yale University School of Medicine, New Haven, CT 06520, USA.
² Department of Cellular and Molecular Physiology, Department of Neuroscience, CNNR program, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: susumu.tomita@yale.edu.

Abstract

There are significant challenges in identifying receptor-specific functional interactors in vivo. In this issue of Neuron, Ge et al. (2018) identify a novel GABA_A receptor (GABA_AR)-interacting protein, Clptm1, that regulates forward trafficking of GABA_ARs and inhibitory transmission.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Neurons
Protein Transport
Proteomics*
Receptors, GABA-A*
gamma-Aminobutyric Acid

Substances

Receptors, GABA-A
gamma-Aminobutyric Acid

Grants and funding

R01 MH115705/MH/NIMH NIH HHS/United States