Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015

Alice Y Guh; Yi Mu; James Baggs; Lisa G Winston; Wendy Bamberg; Carol Lyons; Monica M Farley; Lucy E Wilson; Stacy M Holzbauer; Erin C Phipps; Zintars G Beldavs; Marion A Kainer; Maria Karlsson; Dale N Gerding; Ghinwa Dumyati

doi:10.1016/j.ajic.2017.11.026

Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015

Am J Infect Control. 2018 Jul;46(7):840-842. doi: 10.1016/j.ajic.2017.11.026. Epub 2018 Jan 9.

Authors

Alice Y Guh¹, Yi Mu², James Baggs², Lisa G Winston³, Wendy Bamberg⁴, Carol Lyons⁵, Monica M Farley⁶, Lucy E Wilson⁷, Stacy M Holzbauer⁸, Erin C Phipps⁹, Zintars G Beldavs¹⁰, Marion A Kainer¹¹, Maria Karlsson², Dale N Gerding¹², Ghinwa Dumyati¹³

Affiliations

¹ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: ggt4@cdc.gov.
² Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA.
³ School of Medicine, University of California, San Francisco, San Francisco, CA.
⁴ Colorado Department of Public Health and Environment, Denver, CO.
⁵ Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, CT.
⁶ Department of Medicine, Emory University, Atlanta, GA; Georgia Emerging Infections Program, Decatur, GA; Atlanta Veterans Affairs Medical Center, Atlanta, GA.
⁷ Maryland Department of Health, Baltimore, MD.
⁸ Minnesota Department of Health, St Paul, MN; Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, GA.
⁹ New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, NM.
¹⁰ Oregon Health Authority, Portland, OR.
¹¹ Tennessee Department of Health, Nashville, TN.
¹² Stritch School of Medicine, Loyola University Chicago, Maywood, IL; Edward Hines, Jr Veterans Affairs Hospital, Hines, IL.
¹³ New York Emerging Infections Program and University of Rochester Medical Center, Rochester, NY.

Abstract

During 2011-2015, the adjusted long-term-care facility onset Clostridium difficile infection incidence rate in persons aged ≥65 years decreased annually by 17.45% (95% confidence interval, 14.53%-20.43%) across 10 US sites. A concomitant decline in inpatient fluoroquinolone use and the C difficile epidemic strain NAP1/027 among persons aged ≥65 years may have contributed to the decrease in long-term-care facility-onset C difficile infection incidence rate.

Keywords: Fluoroquinolone; NAP1/027.

Published by Elsevier Inc.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Clostridium Infections / epidemiology*
Humans
Incidence
Long-Term Care / statistics & numerical data*
Residential Facilities*
Retrospective Studies
United States / epidemiology

Grants and funding

CC999999/Intramural CDC HHS/United States