Changes in bone marrow innate lymphoid cell subsets in monoclonal gammopathy: target for IMiD therapy

Blood Adv. 2017 Nov 20;1(25):2343-2347. doi: 10.1182/bloodadvances.2017012732. eCollection 2017 Nov 28.

Abstract

Altered number, subset composition, and function of bone marrow innate lymphoid cells are early events in monoclonal gammopathies.Pomalidomide therapy leads to reduction in Ikzf1 and Ikzf3 and enhanced human innate lymphoid cell function in vivo.