Risky Business: The Circuits that Impact Stress-Induced Decision-Making

Amy F T Arnsten; Daeyeol Lee; Christopher Pittenger

doi:10.1016/j.cell.2017.11.004

Risky Business: The Circuits that Impact Stress-Induced Decision-Making

Cell. 2017 Nov 16;171(5):992-993. doi: 10.1016/j.cell.2017.11.004.

Authors

Amy F T Arnsten¹, Daeyeol Lee², Christopher Pittenger³

Affiliations

¹ Departments of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Child Study Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: amy.arnsten@yale.edu.
² Departments of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA.
³ Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA; Child Study Center, Yale University School of Medicine, New Haven, CT 06510, USA.

PMID: 29149614
DOI: 10.1016/j.cell.2017.11.004

Abstract

How does stress promote risky decision-making? Friedman et al. find that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animals insensitive to potential losses. This may help explain how stress contributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette syndrome.

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MeSH terms

Animals
Basal Ganglia
Corpus Striatum
Decision Making*
Prefrontal Cortex
Tourette Syndrome*