Hunting for the mutant without the MAP(K)

Leon Tejwani; Janghoo Lim

doi:10.1038/cr.2017.140

Hunting for the mutant without the MAP(K)

Cell Res. 2017 Dec;27(12):1403-1404. doi: 10.1038/cr.2017.140. Epub 2017 Nov 14.

Authors

Leon Tejwani^{1

2

3}, Janghoo Lim^{1

2

3

4}

Affiliations

¹ Yale University, Interdepartmental Neuroscience Program, 295 Congress Avenue BCMM454C, New Haven, CT 06510, USA.
² Yale University School of Medicine, Department of Neuroscience, New Haven, CT 06510, USA.
³ Yale University School of Medicine, Program in Cellular Neuroscience, Neurodegeneration and Repair, New Haven, CT 06510, USA.
⁴ Yale University School of Medicine, Department of Genetics, New Haven, CT 06510, USA.

Abstract

In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington's disease (HD) pathology. The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.

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MeSH terms

Animals
Disease Models, Animal
Huntingtin Protein
Huntington Disease*
Mitogen-Activated Protein Kinase 11

Substances

Huntingtin Protein
Mitogen-Activated Protein Kinase 11

Abstract

Publication types

MeSH terms

Substances

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