Pursuit of Noncovalent Interactions for Strategic Site-Selective Catalysis

F Dean Toste; Matthew S Sigman; Scott J Miller

doi:10.1021/acs.accounts.6b00613

Pursuit of Noncovalent Interactions for Strategic Site-Selective Catalysis

Acc Chem Res. 2017 Mar 21;50(3):609-615. doi: 10.1021/acs.accounts.6b00613.

Authors

F Dean Toste¹, Matthew S Sigman², Scott J Miller³

Affiliations

¹ Department of Chemistry, University of California , Berkeley, California 94720, United States.
² Department of Chemistry, University of Utah , 315 S. 1400 E., Salt Lake City, Utah 84112, United States.
³ Department of Chemistry, Yale University , 225 Prospect Street, New Haven, Connecticut 06520, United States.

Abstract

Selective reactions on structures of high complexity can move beyond the mind's eye and proof-of-principle. Enhanced understanding of noncovalent interactions and their interdependence, revealed through analysis of multiple parameters, should accelerate the discovery of efficient reactions in highly complex molecular environments.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Catalytic Domain*
Hydrogen / chemistry
Molecular Structure
Stereoisomerism
Thermodynamics

Substances

Hydrogen

Grants and funding

R01 GM121383/GM/NIGMS NIH HHS/United States