No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs

Will Bailis; Justin A Shyer; Michael Chiorazzi; Richard A Flavell

doi:10.1016/j.ccell.2017.08.013

No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8⁺ TILs

Cancer Cell. 2017 Sep 11;32(3):280-281. doi: 10.1016/j.ccell.2017.08.013.

Authors

Will Bailis¹, Justin A Shyer¹, Michael Chiorazzi¹, Richard A Flavell²

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
² Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: richard.flavell@yale.edu.

Abstract

The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8⁺ TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.

Publication types

Comment

MeSH terms

Fatty Acids
Glucose*
Humans
Lymphocytes, Tumor-Infiltrating / immunology*
Oxygen
Tumor Microenvironment / immunology

Substances

Fatty Acids
Glucose
Oxygen

Grants and funding

T32 AI007019/AI/NIAID NIH HHS/United States