Small-Molecule Modulation of Protein Homeostasis

George M Burslem; Craig M Crews

doi:10.1021/acs.chemrev.7b00077

Small-Molecule Modulation of Protein Homeostasis

Chem Rev. 2017 Sep 13;117(17):11269-11301. doi: 10.1021/acs.chemrev.7b00077. Epub 2017 Aug 4.

Authors

George M Burslem¹, Craig M Crews¹

Affiliation

¹ Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University , 219 Prospect Street, New Haven, Connecticut 06511, United States.

PMID: 28777566
DOI: 10.1021/acs.chemrev.7b00077

Abstract

Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with small molecules and compare the various systems available.

Publication types

Review

MeSH terms

Humans
Immunosuppressive Agents / chemistry
Immunosuppressive Agents / metabolism
Proteasome Endopeptidase Complex / chemistry
Proteasome Endopeptidase Complex / metabolism
Proteasome Inhibitors / chemistry
Proteasome Inhibitors / metabolism
Protein Binding
Protein Interaction Domains and Motifs
Proteins / metabolism*
Small Molecule Libraries / chemistry*
Small Molecule Libraries / metabolism
Ubiquitin / antagonists & inhibitors
Ubiquitin / metabolism

Substances

Immunosuppressive Agents
Proteasome Inhibitors
Proteins
Small Molecule Libraries
Ubiquitin
Proteasome Endopeptidase Complex