Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension

Jeffrey D Marshall; Maor Sauler; Adriano Tonelli; Youlan Rao; Richard Bucala; Patty J Lee; Wassim H Fares

doi:10.1177/2045893217724141

Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension

Pulm Circ. 2017 Jul-Sep;7(3):730-733. doi: 10.1177/2045893217724141. Epub 2017 Jul 31.

Authors

Jeffrey D Marshall¹, Maor Sauler¹, Adriano Tonelli², Youlan Rao³, Richard Bucala⁴, Patty J Lee¹, Wassim H Fares¹

Affiliations

¹ 1 Yale University School of Medicine, Section of Pulmonary, Critical Care, & Sleep Medicine, New Haven, CT, USA.
² 2 Cleveland Clinic, Department of Pulmonary and Critical Care, Cleveland, OH, USA.
³ 3 United Therapeutics Corporation, Research Triangle Park, NC, USA.
⁴ 4 Yale University School of Medicine, Section of Rheumatology, New Haven, CT, USA.

Abstract

Macrophage migration inhibitory factor (MIF) and 22 a priori selected biomarkers were measured from pulmonary arterial hypertension (PAH) patients. Significant positive correlations were found between MIF and several angiogenic factors suggesting a possible MIF regulation role in PAH angiogenesis and pathobiology, but simultaneously highlighting the biomarkers profiling complexity in PAH.

Keywords: angiogenesis; biomarker; pulmonary arterial hypertension.

Abstract

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