Rad52, Maestro of Inverse Strand Exchange

Youngho Kwon; Patrick Sung

doi:10.1016/j.molcel.2017.06.015

Rad52, Maestro of Inverse Strand Exchange

Mol Cell. 2017 Jul 6;67(1):1-3. doi: 10.1016/j.molcel.2017.06.015.

Authors

Youngho Kwon¹, Patrick Sung²

Affiliations

¹ Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06512, USA. Electronic address: youngho.kwon@yale.edu.
² Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, CT 06512, USA.

PMID: 28686872
DOI: 10.1016/j.molcel.2017.06.015

Abstract

In this issue of Molecular Cell, Mazina et al. (2017) describe how the Rad52 protein mediates RNA-dependent DNA double-strand break repair via inverse strand exchange. This finding sheds light on how eukaryotes utilize RNA to repair chromosome breaks.

Keywords: RNA-DNA hybrid; RNA-templated DNA repair; Rad51; Rad52; homologous recombination; inverse strand exchange.

MeSH terms

DNA Breaks, Double-Stranded
DNA Repair*
DNA-Binding Proteins / genetics
Rad51 Recombinase / genetics*
Rad52 DNA Repair and Recombination Protein / genetics
Recombination, Genetic
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae Proteins / genetics

Substances

DNA-Binding Proteins
Rad52 DNA Repair and Recombination Protein
Saccharomyces cerevisiae Proteins
Rad51 Recombinase