The ongoing saga of the mechanism(s) of MHC class I-restricted cross-presentation

Curr Opin Immunol. 2017 Jun:46:89-96. doi: 10.1016/j.coi.2017.03.015. Epub 2017 May 18.

Abstract

Cross-presentation is an MHC-I antigen processing pathway that results in the presentation of peptides from exogenous viral, bacterial, parasitic, and tumor antigens and ultimately leads to priming of naïve CD8+ T cells. This process involves several cellular compartments and multiple components. Successful generation of MHC-I-peptide complexes requires that these components act together in a coordinated fashion. We discuss recent findings on the source of MHC-I, the role of the TAP transporter, the importance of intracellular trafficking events, mechanisms of antigen access the cytosol, and how innate immune signals can affect presentation, with an emphasis on how these pathways compare to conventional antigen presentation and how they correlate with existing data.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Antigens / immunology
  • Antigens / metabolism
  • Biological Transport
  • Cross-Priming / immunology*
  • Cytosol / immunology
  • Cytosol / metabolism
  • Epitopes, T-Lymphocyte / immunology
  • Epitopes, T-Lymphocyte / metabolism
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Peptides / immunology
  • Peptides / metabolism
  • Signal Transduction
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / metabolism

Substances

  • Antigens
  • Epitopes, T-Lymphocyte
  • Histocompatibility Antigens Class I
  • Peptides