Mitochondria Bioenergetic and Cognitive Functions: The Cannabinoid Link

Giacomo Mancini; Tamas L Horvath

doi:10.1016/j.tcb.2017.04.003

Mitochondria Bioenergetic and Cognitive Functions: The Cannabinoid Link

Trends Cell Biol. 2017 Jun;27(6):391-392. doi: 10.1016/j.tcb.2017.04.003. Epub 2017 May 6.

Authors

Giacomo Mancini¹, Tamas L Horvath²

Affiliations

¹ Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
² Program in Integrative Cell Signalling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Anatomy and Histology, University of Veterinary Medicine, Budapest 1078, Hungary. Electronic address: tamas.horvath@yale.edu.

PMID: 28487182
DOI: 10.1016/j.tcb.2017.04.003

Abstract

Despite the well-known role of chronic mitochondrial dysfunction in the pathophysiology of the brain, the impact of acute impairment of mitochondrial activity by cannabinoids on higher brain functions is unknown. In a recent paper in Nature, Hebert-Chatelain et al. elegantly uncovered the essential role that bioenergetic processes have in the regulation of higher brain functions, such as learning and memory.

Keywords: brain; cannabinoid receptor 1; learning; memory; mitochondria.

Publication types

Review
Comment

MeSH terms

Animals
Cannabinoids / metabolism*
Cognition*
Energy Metabolism*
Humans
Mitochondria / metabolism*
Models, Biological
Signal Transduction

Substances

Cannabinoids