Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

Karen K Hirschi; Stefania Nicoli; Kenneth Walsh

doi:10.1016/j.devcel.2017.03.020

Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

Dev Cell. 2017 Apr 10;41(1):7-9. doi: 10.1016/j.devcel.2017.03.020.

Authors

Karen K Hirschi¹, Stefania Nicoli², Kenneth Walsh³

Affiliations

¹ Department of Medicine, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: karen.hirschi@yale.edu.
² Department of Medicine, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06511, USA; Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511, USA; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: stefania.nicoli@yale.edu.
³ Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.

Abstract

Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-HSPC.

Publication types

Comment

MeSH terms

Cell Differentiation
Cell Lineage*
Hematopoiesis
Hematopoietic Stem Cells / cytology
Trees*

Grants and funding

R01 HL128064/HL/NHLBI NIH HHS/United States