RNA Methylation Clears the Way

Cassandra Kontur; Antonio Giraldez

doi:10.1016/j.devcel.2017.02.024

RNA Methylation Clears the Way

Dev Cell. 2017 Mar 13;40(5):427-428. doi: 10.1016/j.devcel.2017.02.024.

Authors

Cassandra Kontur¹, Antonio Giraldez²

Affiliations

¹ Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
² Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: antonio.giraldez@yale.edu.

PMID: 28292421
DOI: 10.1016/j.devcel.2017.02.024

Abstract

During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N⁶- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.

Publication types

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MeSH terms

Gene Expression Regulation, Developmental
Methylation
RNA Stability
RNA, Messenger / genetics
RNA, Messenger, Stored / genetics*
Zygote*

Substances

RNA, Messenger
RNA, Messenger, Stored