Novel Developments in Leukopenia and Pancytopenia

Chisom Onuoha; Junaid Arshad; John Astle; Mina Xu; Stephanie Halene

doi:10.1016/j.pop.2016.07.005

Novel Developments in Leukopenia and Pancytopenia

Prim Care. 2016 Dec;43(4):559-573. doi: 10.1016/j.pop.2016.07.005.

Authors

Chisom Onuoha¹, Junaid Arshad¹, John Astle², Mina Xu³, Stephanie Halene⁴

Affiliations

¹ Department of Medicine, St. Mary's Hospital, Waterbury, CT, USA.
² Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
³ Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
⁴ Section of Hematology, Department of Internal Medicine, Yale Comprehensive Cancer Center, Yale University School of Medicine, 300 George Street, 786E, New Haven, CT 06511, USA. Electronic address: Stephanie.halene@yale.edu.

PMID: 27866577
DOI: 10.1016/j.pop.2016.07.005

Abstract

Cytopenias are not disease entities in and of themselves; rather, they are the expression of various underlying disease processes. Careful attention to details in patients' presentation, careful history and examination, as well as attention to the ancillary parameters of the complete blood count with a peripheral blood smear can point the clinician toward the appropriate workup. Causes of cytopenias can be inherited or acquired; the latter include medication related, autoimmune, or neoplastic causes. Emergencies need to be recognized in a timely fashion and expert consultation obtained.

Keywords: Aleukemic leukemia; Clonal hematopoiesis; Hemophagocytosis; Large granular lymphocytosis; Leukopenia; Neutropenia; Pancytopenia.

Publication types

Review

MeSH terms

Hematologic Tests
Humans
Leukopenia / diagnosis*
Leukopenia / etiology*
Pancytopenia / diagnosis*
Pancytopenia / etiology*
Primary Health Care*