Update on innate immunity and perspectives on metabolite regulation in acute pancreatitis

Curr Opin Gastroenterol. 2016 Nov;32(6):507-512. doi: 10.1097/MOG.0000000000000311.

Abstract

Purpose of review: Acute pancreatitis is a major cause of gastrointestinal morbidity for which specific therapy is greatly needed to prevent progression to and induce resolution of severe disease.

Recent findings: Innate immune components and metabolite signaling are recently identified as strong determinants of disease severity and resolution in acute pancreatitis and this work will be discussed herein.

Summary: Targeting innate immune cell populations and metabolite signaling pathways in acute pancreatitis may result in broader and ultimately more efficacious re-direction of the inflammatory programme toward disease resolution and improved clinical outcomes.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Disease
  • Animals
  • Humans
  • Immunity, Innate / physiology*
  • Inflammation Mediators / metabolism
  • Lipid Metabolism / immunology
  • Molecular Targeted Therapy
  • Pancreatitis / immunology*
  • Pancreatitis / metabolism
  • Pancreatitis / therapy
  • Signal Transduction / immunology

Substances

  • Inflammation Mediators