Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Pigment Cell Melanoma Res. 2016 Nov;29(6):627-642. doi: 10.1111/pcmr.12538. Epub 2016 Oct 22.

Abstract

Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.

Keywords: brain metastasis; clinical trials; experimental models; leptomeningeal disease; tumor microenvironment.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / secondary*
  • Brain Neoplasms / therapy
  • Humans
  • Melanoma / pathology*
  • Melanoma / therapy