CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha

Immunity. 2016 Sep 20;45(3):583-596. doi: 10.1016/j.immuni.2016.08.002. Epub 2016 Aug 23.

Abstract

Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body's homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b(+)CD11c(+)MHCII(+) MNPs in multiple organs including adipose tissues. Depleting CD301b(+) MNPs in vivo led to a significant weight loss with increased insulin sensitivity and a marked reduction in serum Resistin-like molecule (RELM) α, a multifunctional cytokine produced by MNPs. Reconstituting RELMα in CD301b(+) MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b(+) MNPs play crucial roles in maintaining glucose metabolism and net energy balance.

Keywords: adipose tissue macrophage; alternatively activated macrophage; glucose metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / metabolism
  • Animals
  • Energy Metabolism / physiology*
  • Female
  • Glucose
  • Insulin / metabolism
  • Insulin Resistance / physiology
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Lectins, C-Type / metabolism*
  • Macrophages / metabolism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Phagocytes / metabolism*

Substances

  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Lectins, C-Type
  • MGL2 protein, mouse
  • Retnla protein, mouse
  • Glucose