Youth-Onset Type 2 Diabetes Consensus Report: Current Status, Challenges, and Priorities

Diabetes Care. 2016 Sep;39(9):1635-42. doi: 10.2337/dc16-1066. Epub 2016 Aug 2.

Abstract

Type 2 diabetes is a significant and increasing burden in adolescents and young adults. Clear strategies for research, prevention, and treatment of the disease in these vulnerable patients are needed. Evidence suggests that type 2 diabetes in children is different not only from type 1 but also from type 2 diabetes in adults. Understanding the unique pathophysiology of type 2 diabetes in youth, as well as the risk of complications and the psychosocial impact, will enable industry, academia, funding agencies, advocacy groups, and regulators to collectively evaluate both current and future research, treatment, and prevention approaches. This Consensus Report characterizes type 2 diabetes in children, evaluates the fundamental differences between childhood and adult disease, describes the current therapeutic options, and discusses challenges to and approaches for developing new treatments.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Age of Onset
  • Allostasis
  • Child
  • Consensus
  • Delivery of Health Care*
  • Diabetes Complications / epidemiology*
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / psychology
  • Diabetes Mellitus, Type 2 / therapy
  • Diet Therapy
  • Disease Management
  • Ethnicity / statistics & numerical data
  • Exercise Therapy
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Minority Groups / statistics & numerical data
  • Risk
  • Risk Reduction Behavior
  • Socioeconomic Factors
  • United States / epidemiology
  • Young Adult

Substances

  • Hypoglycemic Agents