Circadian clock control of hepatic lipid metabolism: role of small heterodimer partner (Shp)

J Investig Med. 2016 Oct;64(7):1158-61. doi: 10.1136/jim-2016-000194. Epub 2016 Jul 29.

Abstract

Hepatic steatosis, the accumulation of triglyceride droplets in the hepatocytes, is a common hepatic pathology seen in subjects with obesity/metabolic syndrome and those with excessive alcohol use. The pathogenesis underlying hepatic steatosis is complex. Recent studies have shown the specific role played by the molecular clock mechanism in the control of lipid metabolism and that the disruption of these tissue clocks may lead to the disturbances in lipid homeostasis. This review reports a novel role of small heterodimer partner in maintaining triglyceride and lipoprotein homeostasis through neuronal PAS domain protein 2.

Keywords: Lipid Metabolism.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Circadian Clocks*
  • Humans
  • Lipid Metabolism*
  • Liver / metabolism*
  • Models, Biological
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction

Substances

  • Receptors, Cytoplasmic and Nuclear
  • nuclear receptor subfamily 0, group B, member 2