Fat Decisions: Leptin Regulates Bone versus Fat in the Marrow

Matthew S Rodeheffer; Mark C Horowitz

doi:10.1016/j.stem.2016.05.006

Fat Decisions: Leptin Regulates Bone versus Fat in the Marrow

Cell Stem Cell. 2016 Jun 2;18(6):684-686. doi: 10.1016/j.stem.2016.05.006.

Authors

Matthew S Rodeheffer¹, Mark C Horowitz²

Affiliations

¹ Department of Molecular, Cell and Developmental Biology, Yale University and the Section of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: matthew.rodeheffer@yale.edu.
² Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT 06510, USA.

PMID: 27257753
DOI: 10.1016/j.stem.2016.05.006

Abstract

Leptin is an adipocyte-derived hormone involved in energy sensing. In this issue of Cell Stem Cell, Yue et al. (2016) show that leptin is a physiologic signal that acts directly on Leptin-Receptor-expressing mesenchymal stromal cells in adult bone marrow to influence their lineage allocation in vivo, inhibiting bone formation and inducing marrow adipogenesis.

Publication types

Comment

MeSH terms

Adipocytes / drug effects
Adipogenesis / drug effects
Bone Marrow / drug effects*
Bone Marrow Cells / drug effects
Bone and Bones / drug effects
Leptin*
Mesenchymal Stem Cells / drug effects

Substances

Leptin

Grants and funding

R24 DK092759/DK/NIDDK NIH HHS/United States