Pharmacologic Therapies in Gastrointestinal Diseases

Med Clin North Am. 2016 Jul;100(4):827-50. doi: 10.1016/j.mcna.2016.03.009.

Abstract

Several key areas in gastroenterology pharmacotherapy are rapidly evolving, including the treatment of hepatitis C virus (HCV), irritable bowel syndrome, gastroesophageal reflux disease (GERD) and peptic ulcer disease. HCV treatment has radically changed in the past 2 years and now most patients are treatment candidates and have a high likelihood of permanent cure. Pharmacotherapy is now first-line treatment for patients with moderate to severe symptoms of irritable bowel syndrome. Proton pump inhibitors (PPIs) are the mainstay of therapy in gastric and duodenal ulcers and GERD, although long-term use carries the risk of several side effects that should be considered.

Keywords: Direct acting antivirals; GERD; Hepatitis C virus; Irritable bowel syndrome; Peptic ulcer disease.

Publication types

  • Review

MeSH terms

  • Antacids / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Antidepressive Agents / therapeutic use
  • Antidiarrheals / therapeutic use
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / adverse effects
  • Antiviral Agents / therapeutic use*
  • Coinfection
  • Dietary Fiber
  • Drug Resistance, Viral
  • Gastroesophageal Reflux / drug therapy
  • Gastrointestinal Agents / administration & dosage
  • Gastrointestinal Agents / adverse effects
  • Gastrointestinal Agents / therapeutic use*
  • Gastrointestinal Diseases / drug therapy*
  • Genotype
  • HIV Infections / epidemiology
  • Helicobacter Infections / drug therapy
  • Hepatitis C / drug therapy*
  • Hepatitis C / epidemiology
  • Histamine H2 Antagonists / therapeutic use
  • Humans
  • Irritable Bowel Syndrome / drug therapy
  • Laxatives / therapeutic use
  • Peptic Ulcer / drug therapy
  • Probiotics / therapeutic use
  • Proton Pump Inhibitors / therapeutic use

Substances

  • Antacids
  • Anti-Bacterial Agents
  • Antidepressive Agents
  • Antidiarrheals
  • Antiviral Agents
  • Dietary Fiber
  • Gastrointestinal Agents
  • Histamine H2 Antagonists
  • Laxatives
  • Proton Pump Inhibitors