Lactic acid polarizes macrophages to a tumor-promoting state

Oncoimmunology. 2015 Mar 19;5(3):e1014774. doi: 10.1080/2162402X.2015.1014774. eCollection 2016 Mar.

Abstract

Tumor-associated macrophages have been associated with a poor prognosis in most types of tumors. However, tumor-derived signals that activate macrophages have not been well defined. We review our recent finding that tumor-derived lactic acid is necessary and sufficient to polarize tumor-associated macrophages to a tumor-promoting state.

Publication types

  • Research Support, N.I.H., Extramural