Red Blood Cell Antibodies in Hematology/Oncology Patients: Interpretation of Immunohematologic Tests and Clinical Significance of Detected Antibodies

Hematol Oncol Clin North Am. 2016 Jun;30(3):635-51. doi: 10.1016/j.hoc.2016.01.006.

Abstract

Red blood cell (RBC) transfusion is a cornerstone of the management of patients with hematology/oncology disorders. However, a potentially deleterious consequence of transfusion is the development of alloantibodies against blood group antigens present on RBCs. Such alloantibodies can be an obstacle in providing compatible units for transfusion. Providers in this arena must fully understand the testing performed by blood banks, as well as the consequences of detected antibodies. This article reviews immunohematologic tests, describes how autoimmune hemolytic anemia is classified by autoantibodies; outlines RBC alloimmunization rates, and presents strategies to prevent/mitigate the impact of RBC alloimmunization.

Keywords: Alloimmunization; Blood banking; Compatibility testing; Hematology/oncology disorders; Immunohematology; Red blood cell alloantibodies; Red blood cell autoantibodies.

Publication types

  • Review

MeSH terms

  • Anemia, Hemolytic, Autoimmune* / blood
  • Anemia, Hemolytic, Autoimmune* / etiology
  • Anemia, Hemolytic, Autoimmune* / immunology
  • Anemia, Hemolytic, Autoimmune* / prevention & control
  • Blood Banks
  • Blood Group Antigens* / blood
  • Blood Group Antigens* / immunology
  • Blood Group Incompatibility* / blood
  • Blood Group Incompatibility* / immunology
  • Blood Group Incompatibility* / prevention & control
  • Erythrocytes* / immunology
  • Erythrocytes* / metabolism
  • Humans
  • Isoantibodies* / blood
  • Isoantibodies* / immunology
  • Neoplasms* / blood supply
  • Neoplasms* / immunology
  • Neoplasms* / therapy
  • Transfusion Reaction*

Substances

  • Blood Group Antigens
  • Isoantibodies